Ok thought of this while setting up a character with someone. But in the Ultimateverse of X-men there was a drug that boosted mutant powers. It allowed colossus the strength to move while in his metal form and gave cyclops and rogue control over their powers. So what if we add that here? it can be something long running not just a one shot thing.
Basically it would be a drug that is super addictive but A grants temp powers to humans though with high risk of OD, B boost to mutants already with powers, C control to those unable to control their powers yet, D as a side effect for someone attempting to get clean the powers overload and go out of control forcing the person to either use more of the drug or suffer through the period that the body purges the drug from their system. Lasting through the purge can either reset powers back to where they were before drug use, temporary lose of powers, powers at a lower level then before but still usable, or permanent depowering